At what point in gestation should Rh negative women receive Rho (D) immunoglobulin?

Rho (D) immunoglobulin is an essential treatment for Rh negative women during pregnancy to prevent Rh sensitization, which can have serious implications for future pregnancies. The recommended timing for administering Rho (D) immunoglobulin is at 28 weeks of gestation.

At this point in pregnancy, the mother's immune response is sufficiently developed, and administering Rho (D) immunoglobulin can help to prevent the formation of antibodies against Rh-positive blood cells that may enter the maternal circulation, particularly during fetal-maternal hemorrhage that can occur throughout pregnancy and at the time of delivery.

In addition to the routine administration at 28 weeks, Rho (D) immunoglobulin is also indicated after any potential bleeding episodes or invasive procedures, but the initial routine dose is at the 28-week mark of gestation. This proactive approach is critical for protecting current and future pregnancies from the risks associated with Rh incompatibility.