What is the required interval between repeated applications of lindane?

Lindane, a medication often used as a treatment for scabies and lice, has specific guidelines regarding the interval between its applications to ensure efficacy and minimize toxicity. The correct choice reflects the recommended practice, which is to allow at least a 12-hour interval between repeated applications. This interval is necessary to reduce the risk of potential side effects and to prevent toxicity, while still effectively treating the infestation.

Applying lindane more frequently than the recommended interval can lead to increased absorption of the drug, raising the likelihood of adverse effects, especially given that lindane is a neurotoxin. Consequently, adhering to a 12-hour interval allows the medication to remain effective while also safeguarding the patient's health by controlling the total dosage over a given timeframe. This guideline is particularly important in clinical practice, as it reflects a balance between effectiveness and safety in treatment protocols.