Which condition are Janeway lesions associated with?

Janeway lesions are specific lesions associated with infective endocarditis, an infection of the inner lining of the heart. These lesions are typically painless, flat, and occur as small erythematous or hemorrhagic spots, often found on the palms and soles. They are a direct result of septic emboli that arise from infected heart valves and can be an important diagnostic indicator for clinicians when assessing for endocarditis.

In contrast, the other conditions listed do not present with Janeway lesions. For instance, syphilis may show different skin manifestations, while pernicious anemia is related to vitamin B12 deficiency and presents with different signs and symptoms, such as neurological changes and macrocytic anemia. Systemic lupus erythematosus can cause various types of skin lesions, but these do not resemble Janeway lesions. Therefore, recognizing Janeway lesions is vital as they serve as a key sign in the diagnosis of infective endocarditis.