Which sign is associated with bruising on the flanks suggesting retroperitoneal hemorrhage?

Grey Turner's sign is characterized by the appearance of bruising, which typically manifests as discoloration or ecchymosis on the flanks, often indicating retroperitoneal hemorrhage. This sign can arise in various conditions that lead to bleeding in the retroperitoneal space, such as pancreatitis, vascular injury, or abdominal trauma. The flanks are the areas on either side of the lower back, and the presence of bruising in these areas serves as a crucial clinical indicator of significant underlying abdominal pathology that may require further evaluation and management.

The other signs mentioned have different clinical significances and relate to other conditions. The hematoma sign isn’t as commonly recognized or used in clinical practice to describe bruising associated with a specific site. McBurney's point specifically points to tenderness in appendicitis, located in the right lower abdomen. Brudzinski's sign is associated with meningitis, indicating neck stiffness and involuntary lifting of the legs when the neck is flexed. Thus, Grey Turner's sign is the most appropriate choice related to the symptoms of retroperitoneal hemorrhage.